I · Three questions a working medical team asks
From review screening to DDI to missing results.
Demo 1 · Systematic review · GLP-1 + cardiovascular outcomes2.1 ms · local
RCT · GLP-1 receptor agonist · MACE primary endpoint · 2018–2025 · n ≥ 500
01Multinational RCT, n=8,300 · MACE HR 0.74 (95% CI 0.62–0.88). Primary endpoint met. PubMed · PMID 35621408 · NEJM · 2022 · Tab. 2
0.96
02Phase 3 vs. SGLT2; composite endpoint widened post-hoc — flagged. ClinicalTrials.gov · NCT0… · 2023 · arm B
0.88
03Internal protocol — your team's screening sheet for the same inclusion criteria. file://review/glp1-mace/screening.xlsx · 2024 · local
0.81
Demo 2 · Retraction & outcome-switching auditscan · weekly
included-in-review studies · retraction-check + outcome-switching · since 2022
01Retraction match — PMID cross-referenced against Retraction Watch; cited paper retracted 2024-08. Retraction Watch · DOI 10.1186/… · retraction notice 2024-08-12
0.97
02Outcome-switching: protocol → publication primary-endpoint changed; secondary became primary. CT.gov · NCT0… · scan · anomaly.research.outcome-switching
0.91
03Local note: investigator team flagged on a separate review's COI table — cross-review consistency. file://reviews/2024-cardiac/COI.csv · local · scan · anomaly.medical.coi-non-disclosure
0.83
Demo 3 · Missing-result audit on the trial registryscan · weekly
CT.gov entries with primary completion ≥ 24 mo ago and no posted result · sponsor: industry
01Phase 3 oncology — primary completion 2022-08, no result, no publication, sponsor still listed. CT.gov · NCT0… · result missing 39 mo
0.92
02Cardiology arm, secondary endpoints reclassified after completion — flagged for outcome-switching. scan · anomaly.research.outcome-switching · 2026-Q1
0.87
03Site investigator listed on three unrelated trials with undisclosed industry consulting. scan · medical.coi-non-disclosure · 2026-Q1
0.79
No patient identifier ever leaves the institution. Public-source caches stay on the workstation.
II · What's included
Trial registry, label, review library.
The Medical bundle activates clinical and pharmacology sources plus the medical scan family. Layer it with Life sciences if your work crosses into genomics; with Legal for regulatory submissions.
- PubMed · ClinicalTrials.gov · Cochrane · ICTRP · EU CTR · medRxivauthenticated bulk + delta · ~1.4 M new abstracts/yr
- openFDA · Retraction Watchlabels + adverse events · retraction notices for cross-check at emit
- Native renderers
prisma with study-flow payload · claims-ledger aggregator profile pico · validation-binder for reg-grade.29-template surface
- Anti-fabrication rail
indago_finding_emit rejects unresolvable evidence_chunk_id — no fabricated PMIDs.guard at emit
- Missing-result · outcome-switching · COI · retraction-checkscan · anomaly.med.unregistered-trial · anomaly.research.outcome-switching · anomaly.med.missing-conflict-disclosure · quality.literature.retraction-check
- Chain-of-custody
Every PRISMA + claims-ledger render appended to the journal. indago_journal(op=verify). See audit chain.21 CFR / GxP — validation-binder framework labels
Sources of record
PubMedClinicalTrials.govCochraneICTRPEU CTRmedRxivopenFDARetraction Watch
II.5 · Sample workflows
Real workflows. Real numbers.
Three workflows shaped for this bundle. Where the box reads Verified, the numbers come from a real run logged in this codebase. Where it reads Pending validation, the workflow shape is implemented and we are still gathering the headline numbers before we publish them.
Workflow 01
Pending validation
Systematic review · GLP-1 · MACE
Cochrane-style reviewers
- InputInclusion criteria: RCT · GLP-1 receptor agonist · MACE primary endpoint · n ≥ 500 · 2018–2025.
- MethodCross-source ranking over PubMed + ClinicalTrials.gov + Cochrane, with
anomaly.research.outcome-switching and anomaly.med.missing-conflict-disclosure scans running in parallel.
- OutputPRISMA flow with Identified → Screened → Included counts plus a CSV of flagged trials.
Weeks → afternoon
Workflow path runs against public sources today — pending a reviewer-team end-to-end test before we publish numbers.
Workflow 02
Pending validation
Pharmacovigilance · missing-result audit
PV office
- InputSponsor portfolio, primary-completion cut-off 24 months prior, industry-sponsored only.
- Method
anomaly.med.unregistered-trial + anomaly.research.outcome-switching + anomaly.med.missing-conflict-disclosure scans over the registry slice.
- OutputWeekly oversight digest with per-trial overdue intervals and outcome-switching deltas.
Overdue trials
Engine runs; pending live PV office run against a real sponsor portfolio.
Workflow 03
Pending validation
Point-of-care DDI · apixaban + clarithromycin
Clinical pharmacists
- InputTwo medication identifiers and patient age band.
- MethodLocal cross-reference of openFDA labels and the trust's internal anticoagulation protocol; flagging where label guidance and protocol diverge.
- OutputRanked DDI card with mechanism, AUC delta, FDA label citation and the internal protocol section.
Sub-second lookup
Lookup latency demonstrable on the cached data — pending hospital EHR-plug-in deployment trial.
Verified workflows are reproducible against the index hash listed in each run. Pending workflows are a written commitment, not a customer quote — we publish numbers only when we have measured them.
Medical bundle · from
€499/ seat / month
· institutional rollouts · all clinical sources · scan family included
III · Also useful for clinical work
Indago is an information-retrieval tool, not a medical device or clinical decision-support system. Outputs are for research and informational purposes only and are not medical advice. "HIPAA-safe by design" refers to local, on-premise data handling; HIPAA compliance remains the responsibility of the operating organisation.