I · Three questions a working bio team asks
From pathway to sequence to symbol audit.
Demo 1 · Pathway lookup with consistency check1.4 ms · local
pathway · mTORC1 · upstream regulators · vertebrate · consistent with KEGG hsa04150
01Canonical · RHEB → mTORC1; TSC1/TSC2 GAP activity, Akt-mediated TSC inhibition. KEGG · hsa04150 · 2025 · node 23
0.96
02XLSX gene table — SEPT2 → 2-Sep Excel coercion flagged. file://lab/draft-v3/supp_genes.xlsx · 2026-04 · scan · anomaly.bio.excel-coerce
0.88
03Review · "RHEB-independent mTOR activation under amino-acid deprivation". PubMed · PMID 38… · 2024 · Sect. 3.2
0.83
Demo 2 · Gene-symbol audit across the supplementary tablesscan · per-file
audit · all gene symbols in supplementary/*.xlsx · flag Excel-coerced dates
01SEPT2 → "2-Sep" coercion in 14 rows of supp_table_3.xlsx. scan · life.symbol.excel-coerce · file://supp/table_3.xlsx
0.99
02MARCH1 / MARCHF1 nomenclature drift across tables — HGNC update 2020. UniProt mapping · 2020 release · 3 affected rows
0.91
Demos illustrative. The engine indexes your pipeline output locally — sequence FASTQs are not re-uploaded.
II · What's included
UniProt, KEGG, Reactome, bioRxiv — plus your pipeline.
Pair with Medical when work crosses into clinical evidence; with Research for the broader scholarly graph.
- UniProt · KEGG · Reactome · bioRxivauthenticated bulk · delta updates · 200 M+ proteins
- Native renderers
materials-regulatory-card · sota-survey-map · claims-ledger aggregator profile materials.29-template surface
- Anti-fabrication rail
indago_finding_emit rejects unresolvable chunk-ids — no fabricated accession numbers.guard at emit
- Gene-symbol drift · Excel-coercescan · anomaly.bio.symbol-collision · anomaly.bio.excel-coerce
- Sequence-quality & integrityFASTQ phred drop · adapter contamination · duplication rate
- Local pipeline indexingFASTQ · BAM · VCF metadata · notebook outputs
Sources of recordUniProtKEGGReactomebioRxiv
Need ChEMBL, HGNC or RCSB PDB? Indago can ingest any of them via URL on demand (indago_learn), but they are not first-class registered sources in this bundle today.
II.5 · Sample workflows
Real workflows. Real numbers.
Three workflows shaped for this bundle. Where the box reads Verified, the numbers come from a real run logged in this codebase. Where it reads Pending validation, the workflow shape is implemented and we are still gathering the headline numbers before we publish them.
Workflow 01
Pending validation
Supplementary-table symbol audit
Genomics core
- InputA manuscript supplementary directory of XLSX/CSV gene-list tables.
- Method
anomaly.bio.excel-coerce + UniProt cross-reference + chunk-resolved citation per coerced row.
- OutputPer-file delta report listing every coerced symbol ("SEPT2 → 2-Sep" class) plus suggested rewrites.
Excel-coerce trap
Scan shape is implemented; pending validation on a real supplementary dataset before publishing a hit-rate.
Workflow 02
Pending validation
Pathway consistency check
Computational biologists
- InputA draft manuscript figure (PDF/SVG) plus the cited pathway ID.
- MethodCross-reference against KEGG canonical + literature search for known deviations.
- OutputAnnotated figure diff with each missing / extra edge flagged against KEGG.
Pre-submission catch
Pending bio-team end-to-end test on a real draft figure before quoting precision.
Workflow 03
Pending validation
Sequence-quality batch QC
Sequencing pipelines
- InputA directory of FASTQ + a quality threshold.
- Method
life.sequence.phred-drop + adapter-contamination + duplication-rate scans.
- OutputPer-file QC card and a single summary CSV for the LIMS.
Pipeline gate
Workflow runs against synthetic FASTQ today — pending a real wet-lab batch for the quote-worthy numbers.
Verified workflows are reproducible against the index hash listed in each run. Pending workflows are a written commitment, not a customer quote — we publish numbers only when we have measured them.
Life sciences bundle · from€499/ seat / month· institutional rollouts · scan family included